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Evkeeza®: evinacumab for injection

  • 効能又は効果、用法及び用量、警告・禁忌を含む注意事項等
    については電子化された添付文書をご参照ください。

EVKEEZA (evinacumab) is used to treat adults and children aged 5 years and older with very high cholesterol caused by a condition called homozygous familial hypercholesterolemia (HoFH). EVKEEZA is used with a low-fat diet and other medicines to bring down cholesterol levels.

EVKEEZA at a glance:

  1. Is used to treat HoFH in adults and children 5 and older in combination with other lipid lowering therapies and low-fat diet
  2. Reduces the the level of LDL-cholesterol in the blood
  3. Is a 60-minute IV infusion, given every 4 weeks

What is HoFH?

  • People with HoFH have extremely high levels of LDL-cholesterol—or ‘bad cholesterol’—from birth.
  • Cholesterol levels this high can lead to heart problems at a early age.
  • HoFH runs in families and it is usually passed down by both father and mother.

EVKEEZA works differently from other cholesterol-lowering treatments

HoFH is a serious disease that is inherited from one's parents that dramatically limits the body’s ability to remove bad cholesterol (LDL-C), which causes extremely high levels of bad cholesterol to remain in the body.

With HoFH, ANGPTL3 (a protein) stops the body from removing bad cholesterol. EVKEEZA was developed to block the effects of ANGPTL3.

Evinacumab, the active substance in Evkeeza, attaches to a protein in the body called ANGPTL3 and blocks its effects. ANGPTL3 is involved in controlling cholesterol levels. When evinacumab blocks the effects of ANGPLT3, the level of LDL-cholesterol in the blood is reduced and problems caused by high LDL-cholesterol levels may also be reduced.

Learn more about EVKEEZA

What is EVKEEZA used for?

EVKEEZA (evinacumab) is used to treat adults and children aged 5 years and older with very high cholesterol caused by a condition called homozygous familial hypercholesterolemia (HoFH). EVKEEZA is used with a low-fat diet and other medicines to bring down cholesterol levels.

Do not use EVKEEZA if:

  • You are allergic to evinacumab or any of the other ingredients in this medicine

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take EVKEEZA. Talk about any health conditions or problems you may have, including:

  • If you are pregnant, think you might be pregnant, or plan to become pregnant, ask your healthcare professional for advice before taking EVKEEZA. EVKEEZA may harm your unborn baby. Tell your healthcare professional if you become pregnant while using EVKEEZA. For people who are able to become pregnant:
    • Your healthcare professional may do a pregnancy test before you start treatment with EVKEEZA.
    • You should use an effective method of birth control during treatment and for at least 5 months after the last dose of EVKEEZA. Talk to your healthcare professional about birth control methods that you can use during this time.
  • If you are breastfeeding or plan to breastfeed, ask your healthcare professional for advice before you are given EVKEEZA. It is not known if EVKEEZA passes into your breast milk. You and your healthcare professional should decide if you will receive EVKEEZA or breastfeed.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements, or alternative medicines.

  • Studies to test how EVKEEZA interacts with other drugs have not been done.